Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn’s Disease

Spatial transcriptomics was performed using 10X Visium

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hg38

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ST of IPF and PCD fistula tracts (n = 3/group) generated 6 spatially correlated clusters

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GEO assay type/library strategy: OTHER, RNA-SEQ

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GEO library strategy=['OTHER', 'RNA-SEQ']

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Adult

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Fistula tract biopsies of 9 individuals with PCD and 6 with IPF

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Fistula tract biopsies of 9 individuals with PCD and 6 with IPF

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Spatial transcriptomics was performed using 10X Visium on idiopathic and Crohn's perianal fistula (N = 3/group).

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Fistula tract biopsies of 9 individuals with PCD and 6 with IPF ... were analyzed using scRNA-Seq

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We subdivided our scRNA-Seq PCD cohort into anti-TNF–treated or anti-TNF–naive groups based on treatment at sampling

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all patients on anti-TNFs later responded to therapy

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Supplementary files enumerated in family SOFT ()

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Public on Jun 17 2025

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tar file containing CellRanger/SpaceRanger output

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Supplementary files format and content: tar file containing CellRanger/SpaceRanger output

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tar file containing CellRanger/SpaceRanger output

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GEO sample source names: Perianal Fistula

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21 GSM records parsed from GEO family SOFT

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Fistula tract biopsies of 9 individuals with PCD and 6 with IPF

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