Most genetic variants associated with complex diseases lie in non-coding regions<sup>1</sup>, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single cells using intestinal biop…
Participants421
Samples732
Reuse8.9/10
Study facts
Organism
Homo sapiens
Platform
10x Genomics Chromium
Age group
adult
Disease groups
—
Anatomical sites
blood, ileum, rectum
Data availability
Processed matrix
Analysis code
Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients e…
Participants199
Samples199
Reuse5.6/10
Study facts
Organism
Homo sapiens
Platform
Illumina HiSeq 2000
Age group
paediatric
Disease groups
—
Anatomical sites
ileum
Data availability
Processed matrix
Human CD atlas study between colon and terminal ileum
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level understanding of its etiology. To characterize…
Participants71
Samples—
Reuse6.7/10
Study facts
Organism
Homo sapiens
Platform
10x 3' v1
Age group
—
Disease groups
—
Anatomical sites
colon, ileum
Data availability
Raw counts
Processed matrix
Analysis code
Reveal the key mediators of inflammation in Crohn's disease undergoing biological treatments
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using scRNA-seq and scATAC-seq data from paired biopsy samples of …
Participants49
Samples85
Reuse7.6/10
Study facts
Organism
Homo sapiens
Platform
10x Genomics Chromium
Age group
adult
Disease groups
—
Anatomical sites
terminal ileum, ascending colon
Data availability
Raw counts
Processed matrix
An immune-cell signature of bacterial sepsis (Patient PBMCs)
Inflammatory bowel disease (IBD) and Sepsis are both characterised by immune dysregulation. Notably, IBD is a factor in the increase in septic infections. However, these two conditions' shared molecular and pathophysiological mechanisms remain unclear. We used 'limma' and 'WGCNA…
Participants45
Samples—
Reuse6.9/10
Study facts
Organism
—
Platform
—
Age group
—
Disease groups
—
Anatomical sites
blood
Data availability
Raw counts
Processed matrix
TI epithelial
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level understanding of its etiology. To characterize…
Participants42
Samples—
Reuse6.0/10
Study facts
Organism
Homo sapiens
Platform
10x Genomics
Age group
—
Disease groups
—
Anatomical sites
epithelium of small intestine, ileal epithelium, ileum, ileum lamina propria, lamina propria of small intestine, small intestine
Data availability
Raw counts
Processed matrix
TI stromal
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level understanding of its etiology. To characterize…
Participants40
Samples—
Reuse5.7/10
Study facts
Organism
Homo sapiens
Platform
10x 3' v2
Age group
adult
Disease groups
—
Anatomical sites
ileal epithelium, ileum, ileum lamina propria, lamina propria of small intestine, small intestine
Data availability
Processed matrix
colon stromal
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level understanding of its etiology. To characterize…
Participants34
Samples—
Reuse6.4/10
Study facts
Organism
Homo sapiens
Platform
10x
Age group
adult
Disease groups
—
Anatomical sites
ascending colon, caecum lamina propria, colon, colonic epithelium, descending colon, lamina propria of mucosa of colon, sigmoid colon, sigmoid colon epithelium, sigmoid colon lamina propria, transverse colon epithelium, transverse colon lamina propria
Data availability
Raw counts
Processed matrix
colon epithelial
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level understanding of its etiology. To characterize…
Participants34
Samples—
Reuse6.0/10
Study facts
Organism
Homo sapiens
Platform
10x
Age group
adult
Disease groups
—
Anatomical sites
ascending colon, caecum epithelium, caecum lamina propria, colon, colonic epithelium, descending colon, lamina propria of mucosa of colon, sigmoid colon, sigmoid colon epithelium, sigmoid colon lamina propria, transverse colon epithelium, transverse colon lamina propria
Data availability
Processed matrix
TL1A-activated Tcells as upstream regulators of perianal fistulizing disease-associated changes in the rectum of Crohn's Disease patients [scRNA-seq]
<h4>Background</h4>Perianal fistulising disease (PFD) is a complication that affects about 20% of patients with Crohn's disease (CD) whose aetiology remains unknown.<h4>Objectives</h4>To identify predisposing events driving fistula formation.<h4>Design</h4>Rectal biopsies from p…