Large-scale whole blood RNA-Seq identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis
<h4>Background & aims</h4>Genetic and microbiome studies across patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have indicated that UC in PSC is a separate disease entity to primary UC, but expression studies for PSC are lacking.<h4>Methods</h4>We …
Participants1,035
Samples—
Reuse5.7/10
Study facts
Organism
Homo sapiens
Platform
Illumina HiSeq2500
Age group
adult
Disease groups
Non-IBD controls, Ulcerative colitis
Anatomical sites
—
Data availability
Analysis code
Transcriptional Drivers of Stricturing Crohns Disease
<h4>Background</h4>Crohn's disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having a substantial impact on biologi…
Participants345
Samples746
Reuse6.7/10
Study facts
Organism
—
Platform
Illumina HiSeq 1000
Age group
paediatric
Disease groups
Crohn's disease, Non-IBD controls
Anatomical sites
—
Data availability
No availability flags resolved yet.
Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.
<h4>Background</h4>Pouchitis is common after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC). Similar to inflammatory bowel disease (IBD), both host genetics and the microbiota are implicated in its pathogenesis. We use the IPAA model of IBD to associate …
Participants205
Samples255
Reuse8.9/10
Study facts
Organism
Homo sapiens
Platform
Illumina MiSeq v2
Age group
adult
Disease groups
—
Anatomical sites
—
Data availability
Analysis code
Paired mucosal j-pouch and afferent limb samples from postoperative ulcerative colitis and familial ademonatous polyposis patients from Mount Sinai Hospital, Toronto. Samples were collected during pouch endoscopy and 16S sequenced.
<h4>Background</h4>Pouchitis is common after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC). Similar to inflammatory bowel disease (IBD), both host genetics and the microbiota are implicated in its pathogenesis. We use the IPAA model of IBD to associate …
Participants204
Samples652
Reuse8.9/10
Study facts
Organism
human gut metagenome
Platform
Illumina MiSeq
Age group
adult
Disease groups
—
Anatomical sites
—
Data availability
Analysis code
The Intestinal Microbiome in Children with Inflammatory Bowel Disease and Lactose Malabsorption
<h4>Background</h4>Dietary exclusion of lactose from patients with inflammatory bowel disease (IBD) persists with speculation that deleterious effects are mediated through intestinal microbes.<h4>Objectives</h4>To compare IBD characteristics and changes in the intestinal microbi…
Participants185
Samples459
Reuse7.7/10
Study facts
Organism
human gut metagenome
Platform
Illumina HiSeq 2500
Age group
paediatric
Disease groups
Crohn's disease, Ulcerative colitis
Anatomical sites
—
Data availability
No availability flags resolved yet.
Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis …
Epigenomic alterations are associated with mucosal microbiota and inflammation in inflammatory bowel disease
Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic mucosa [50 Crohn's disease (CD); 80 ul…
No association between the faecal microbiome and the presence of genuine irritable bowel syndrome symptoms in patients with quiescent inflammatory bowel disease
<h4>Background</h4>The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD patients is uncertain. We aimed to resol…
Participants270
Samples—
Reuse4.4/10
Study facts
Organism
—
Platform
Illumina MiSeq
Age group
adult
Disease groups
—
Anatomical sites
—
Data availability
No availability flags resolved yet.
Fungal microbiota dysbiosis in IBD PMID: 26843508 RUN1
<h4>Objective</h4>The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbi…
Participants273
Samples—
Reuse4.3/10
Study facts
Organism
—
Platform
—
Age group
—
Disease groups
Non-IBD controls
Anatomical sites
—
Data availability
No availability flags resolved yet.
Fungal microbiota dysbiosis in IBD PMID: 26843508 RUN2
<h4>Objective</h4>The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbi…